Suggestive GxE (P < 5e-6)

chr17_71354811_G_A

Allele freq

Stratified OR

G param by E
GG GA AA GA AA
redmeatqcm_v2=0 1 0.74 (0.65-0.85) 1.37 (0.52-3.6) 0.74 (0.65-0.85) 1.37 (0.52-3.6)
p0 P= 1 P= 9e-06 P= 0.53 P= 9e-06 P= 0.53
redmeatqcm_v2=1 1.23 (1.17-1.29) 1.57 (1.38-1.79) 2.66 (0.92-7.72) 1.28 (1.12-1.45) 2.17 (0.75-6.27)
p1 P= 3e-17 P= 2.3e-11 P= 0.071 P= 0.00021 P= 0.15
E param by G
redmeatqcm_v2 1.23 (1.17-1.29) 2.12 (1.74-2.58) 1.95 (0.4-9.48)
p P= 3e-17 P= 8.6e-14 P= 0.41

Interaction Plot

Locuszoom

chr9_120653523_T_G

Allele freq

Stratified OR

G param by E
TT TG GG TG GG
redmeatqcm_v2=0 1 1.2 (1.07-1.35) 1.77 (0.83-3.79) 1.2 (1.07-1.35) 1.77 (0.83-3.79)
p0 P= 1 P= 0.0017 P= 0.14 P= 0.0017 P= 0.14
redmeatqcm_v2=1 1.29 (1.23-1.36) 1.08 (0.98-1.18) 0.96 (0.51-1.81) 0.83 (0.76-0.91) 0.74 (0.39-1.39)
p1 P= 4.5e-25 P= 0.13 P= 0.9 P= 5.8e-05 P= 0.35
E param by G
redmeatqcm_v2 1.29 (1.23-1.36) 0.89 (0.77-1.04) 0.54 (0.19-1.56)
p P= 4.5e-25 P= 0.14 P= 0.26

Interaction Plot

Locuszoom

chr4_31160820_G_A

Allele freq

Stratified OR

G param by E
GG GA AA GA AA
redmeatqcm_v2=0 1 0.8 (0.72-0.9) 0.48 (0.22-1.05) 0.8 (0.72-0.9) 0.48 (0.22-1.05)
p0 P= 1 P= 0.00011 P= 0.066 P= 0.00011 P= 0.066
redmeatqcm_v2=1 1.23 (1.17-1.29) 1.49 (1.33-1.66) 0.81 (0.35-1.88) 1.21 (1.09-1.35) 0.66 (0.29-1.53)
p1 P= 1.2e-16 P= 9.4e-13 P= 0.63 P= 0.00031 P= 0.34
E param by G
redmeatqcm_v2 1.23 (1.17-1.29) 1.85 (1.58-2.17) 1.69 (0.51-5.61)
p P= 1.2e-16 P= 5.2e-14 P= 0.39

Interaction Plot

Locuszoom

chr9_120290042_A_G

Allele freq

Stratified OR

G param by E
AA AG GG AG GG
redmeatqcm_v2=0 1 1.25 (1.09-1.42) 1.31 (0.43-3.98) 1.25 (1.09-1.42) 1.31 (0.43-3.98)
p0 P= 1 P= 0.0011 P= 0.63 P= 0.0011 P= 0.63
redmeatqcm_v2=1 1.29 (1.22-1.35) 1.07 (0.97-1.2) 0.5 (0.2-1.25) 0.84 (0.76-0.93) 0.39 (0.15-0.97)
p1 P= 2.2e-24 P= 0.19 P= 0.14 P= 0.00055 P= 0.044
E param by G
redmeatqcm_v2 1.29 (1.22-1.35) 0.86 (0.73-1.02) 0.38 (0.09-1.68)
p P= 2.2e-24 P= 0.084 P= 0.2

Interaction Plot

Locuszoom

chr8_122247679_C_G

Allele freq

Stratified OR

G param by E
CC CG GG CG GG
redmeatqcm_v2=0 1 1.03 (0.98-1.09) 1.07 (0.98-1.16) 1.03 (0.98-1.09) 1.07 (0.98-1.16)
p0 P= 1 P= 0.24 P= 0.14 P= 0.24 P= 0.14
redmeatqcm_v2=1 1.38 (1.29-1.46) 1.24 (1.16-1.31) 1.14 (1.05-1.24) 0.9 (0.86-0.94) 0.83 (0.77-0.89)
p1 P= 4.1e-24 P= 4.7e-12 P= 0.0023 P= 6e-06 P= 3.8e-07
E param by G
redmeatqcm_v2 1.38 (1.29-1.46) 1.2 (1.12-1.27) 1.07 (0.95-1.19)
p P= 4.1e-24 P= 1.5e-08 P= 0.25

Interaction Plot

Locuszoom

chr1_21495668_G_T

Allele freq

Stratified OR

G param by E
GG GT TT GT TT
redmeatqcm_v2=0 1 1.16 (1.07-1.26) 1.61 (1.07-2.44) 1.16 (1.07-1.26) 1.61 (1.07-2.44)
p0 P= 1 P= 0.00048 P= 0.023 P= 0.00048 P= 0.023
redmeatqcm_v2=1 1.3 (1.23-1.36) 1.16 (1.07-1.26) 1.11 (0.76-1.62) 0.9 (0.83-0.96) 0.86 (0.59-1.25)
p1 P= 3.7e-25 P= 0.00018 P= 0.59 P= 0.0031 P= 0.42
E param by G
redmeatqcm_v2 1.3 (1.23-1.36) 1 (0.9-1.12) 0.69 (0.38-1.24)
p P= 3.7e-25 P= 0.94 P= 0.21

Interaction Plot

Locuszoom

chr3_29246192_C_T

Allele freq

Stratified OR

G param by E
CC CT TT CT TT
redmeatqcm_v2=0 1 0.81 (0.72-0.92) 0.38 (0.15-0.98) 0.81 (0.72-0.92) 0.38 (0.15-0.98)
p0 P= 1 P= 0.00071 P= 0.046 P= 0.00071 P= 0.046
redmeatqcm_v2=1 1.23 (1.18-1.3) 1.53 (1.36-1.72) 0.84 (0.31-2.26) 1.24 (1.1-1.39) 0.68 (0.25-1.83)
p1 P= 8e-18 P= 2.6e-12 P= 0.73 P= 0.00025 P= 0.44
E param by G
redmeatqcm_v2 1.23 (1.18-1.3) 1.88 (1.58-2.24) 2.21 (0.46-10.48)
p P= 8e-18 P= 1.6e-12 P= 0.32

Interaction Plot

Locuszoom

chr1_21209766_T_A

Allele freq

Stratified OR

G param by E
TT TA AA TA AA
redmeatqcm_v2=0 1 1.16 (1.07-1.26) 1.79 (1.18-2.71) 1.16 (1.07-1.26) 1.79 (1.18-2.71)
p0 P= 1 P= 0.0005 P= 0.006 P= 0.0005 P= 0.006
redmeatqcm_v2=1 1.3 (1.23-1.36) 1.18 (1.09-1.27) 1.11 (0.76-1.62) 0.91 (0.84-0.97) 0.86 (0.59-1.25)
p1 P= 5.2e-25 P= 6.2e-05 P= 0.58 P= 0.0076 P= 0.42
E param by G
redmeatqcm_v2 1.3 (1.23-1.36) 1.02 (0.91-1.14) 0.62 (0.35-1.12)
p P= 5.2e-25 P= 0.79 P= 0.11

Interaction Plot

Locuszoom

chr15_100002029_C_T

Allele freq

Stratified OR

G param by E
CC CT TT CT TT
redmeatqcm_v2=0 1 1.01 (0.94-1.09) 1.13 (1.04-1.22) 1.01 (0.94-1.09) 1.13 (1.04-1.22)
p0 P= 1 P= 0.77 P= 0.0023 P= 0.77 P= 0.0023
redmeatqcm_v2=1 1.4 (1.27-1.55) 1.35 (1.25-1.46) 1.27 (1.17-1.38) 0.96 (0.9-1.03) 0.9 (0.85-0.97)
p1 P= 1.1e-11 P= 3.1e-13 P= 1.3e-08 P= 0.27 P= 0.004
E param by G
redmeatqcm_v2 1.4 (1.27-1.55) 1.34 (1.26-1.42) 1.12 (1.05-1.2)
p P= 1.1e-11 P= 9.8e-21 P= 0.00047

Interaction Plot

Locuszoom

chr8_112374447_C_T

Allele freq

Stratified OR

G param by E
CC CT TT CT TT
redmeatqcm_v2=0 1 1.06 (0.96-1.17) 1.14 (1.03-1.26) 1.06 (0.96-1.17) 1.14 (1.03-1.26)
p0 P= 1 P= 0.28 P= 0.0085 P= 0.28 P= 0.0085
redmeatqcm_v2=1 1.48 (1.3-1.69) 1.43 (1.28-1.58) 1.33 (1.2-1.47) 0.96 (0.88-1.05) 0.89 (0.82-0.97)
p1 P= 2.6e-09 P= 2.4e-11 P= 7.7e-08 P= 0.36 P= 0.0086
E param by G
redmeatqcm_v2 1.48 (1.3-1.69) 1.35 (1.26-1.44) 1.16 (1.09-1.23)
p P= 2.6e-09 P= 1.9e-19 P= 8.8e-07

Interaction Plot

Locuszoom

chr18_21029284_C_T

Allele freq

Stratified OR

G param by E
CC CT TT CT TT
redmeatqcm_v2=0 1 0.76 (0.65-0.88) 0.29 (0.05-1.66) 0.76 (0.65-0.88) 0.29 (0.05-1.66)
p0 P= 1 P= 0.00026 P= 0.16 P= 0.00026 P= 0.16
redmeatqcm_v2=1 1.24 (1.18-1.3) 1.53 (1.33-1.76) 2.42 (0.51-11.43) 1.23 (1.08-1.41) 1.96 (0.41-9.23)
p1 P= 2.2e-18 P= 2.8e-09 P= 0.26 P= 0.0024 P= 0.4
E param by G
redmeatqcm_v2 1.24 (1.18-1.3) 2.02 (1.63-2.5) 8.37 (0.5-141.39)
p P= 2.2e-18 P= 1.6e-10 P= 0.14

Interaction Plot

Locuszoom

chr20_51479759_G_T

Allele freq

Stratified OR

G param by E
GG GT TT GT TT
redmeatqcm_v2=0 1 1.4 (1.15-1.7) 1.14 (0.1-12.81) 1.4 (1.15-1.7) 1.14 (0.1-12.81)
p0 P= 1 P= 0.00065 P= 0.92 P= 0.00065 P= 0.92
redmeatqcm_v2=1 1.28 (1.22-1.34) 0.96 (0.82-1.13) 1.43 (0.32-6.27) 0.75 (0.64-0.88) 1.12 (0.25-4.91)
p1 P= 1.2e-23 P= 0.63 P= 0.64 P= 0.0004 P= 0.88
E param by G
redmeatqcm_v2 1.28 (1.22-1.34) 0.69 (0.53-0.89) 1.25 (0.09-18.01)
p P= 1.2e-23 P= 0.004 P= 0.87

Interaction Plot

Locuszoom

chr2_42324419_T_A

Allele freq

Stratified OR

G param by E
TT TA AA TA AA
redmeatqcm_v2=0 1 1.08 (1.01-1.15) 1.14 (1.06-1.23) 1.08 (1.01-1.15) 1.14 (1.06-1.23)
p0 P= 1 P= 0.015 P= 0.00045 P= 0.015 P= 0.00045
redmeatqcm_v2=1 1.39 (1.3-1.5) 1.35 (1.27-1.45) 1.25 (1.16-1.35) 0.97 (0.92-1.02) 0.9 (0.84-0.96)
p1 P= 4.3e-19 P= 1.9e-19 P= 5.9e-09 P= 0.25 P= 0.00072
E param by G
redmeatqcm_v2 1.39 (1.3-1.5) 1.25 (1.18-1.33) 1.09 (1.01-1.19)
p P= 4.3e-19 P= 9.4e-14 P= 0.034

Interaction Plot

Locuszoom

chr10_29013189_C_T

Allele freq

Stratified OR

G param by E
CC CT TT CT TT
redmeatqcm_v2=0 1 0.89 (0.83-0.95) 0.81 (0.67-0.98) 0.89 (0.83-0.95) 0.81 (0.67-0.98)
p0 P= 1 P= 0.00022 P= 0.028 P= 0.00022 P= 0.028
redmeatqcm_v2=1 1.19 (1.13-1.26) 1.28 (1.2-1.37) 1.26 (1.07-1.49) 1.07 (1.02-1.13) 1.06 (0.9-1.25)
p1 P= 3.7e-11 P= 3e-14 P= 0.0063 P= 0.0096 P= 0.5
E param by G
redmeatqcm_v2 1.19 (1.13-1.26) 1.44 (1.33-1.56) 1.56 (1.21-2.02)
p P= 3.7e-11 P= 6.9e-19 P= 0.00071

Interaction Plot

Locuszoom

chr13_62734417_A_G

Allele freq

Stratified OR

G param by E
AA AG GG AG GG
redmeatqcm_v2=0 1 0.9 (0.84-0.96) 0.8 (0.62-1.04) 0.9 (0.84-0.96) 0.8 (0.62-1.04)
p0 P= 1 P= 0.002 P= 0.094 P= 0.002 P= 0.094
redmeatqcm_v2=1 1.21 (1.15-1.27) 1.33 (1.25-1.43) 1.3 (1.04-1.62) 1.11 (1.04-1.17) 1.08 (0.87-1.34)
p1 P= 3.9e-13 P= 4.7e-17 P= 0.019 P= 0.00058 P= 0.5
E param by G
redmeatqcm_v2 1.21 (1.15-1.27) 1.48 (1.36-1.62) 1.61 (1.14-2.29)
p P= 3.9e-13 P= 3.9e-18 P= 0.0073

Interaction Plot

Locuszoom

chr1_41466550_T_A

Allele freq

Stratified OR

G param by E
TT TA AA TA AA
redmeatqcm_v2=0 1 1.1 (1.04-1.17) 1.12 (1.04-1.21) 1.1 (1.04-1.17) 1.12 (1.04-1.21)
p0 P= 1 P= 0.0011 P= 0.0044 P= 0.0011 P= 0.0044
redmeatqcm_v2=1 1.41 (1.32-1.51) 1.33 (1.25-1.42) 1.26 (1.17-1.36) 0.94 (0.9-0.99) 0.89 (0.84-0.95)
p1 P= 1.9e-22 P= 6.7e-19 P= 2.6e-09 P= 0.022 P= 0.00064
E param by G
redmeatqcm_v2 1.41 (1.32-1.51) 1.21 (1.14-1.28) 1.13 (1.03-1.23)
p P= 1.9e-22 P= 7.3e-10 P= 0.0092

Interaction Plot

Locuszoom

chr3_27633795_G_A

Allele freq

Stratified OR

G param by E
GG GA AA GA AA
redmeatqcm_v2=0 1 1.13 (1.06-1.2) 1.19 (1.11-1.28) 1.13 (1.06-1.2) 1.19 (1.11-1.28)
p0 P= 1 P= 0.00036 P= 2.5e-06 P= 0.00036 P= 2.5e-06
redmeatqcm_v2=1 1.45 (1.34-1.57) 1.41 (1.31-1.51) 1.37 (1.27-1.47) 0.97 (0.92-1.03) 0.94 (0.88-1)
p1 P= 1.1e-18 P= 3.3e-21 P= 7.5e-16 P= 0.32 P= 0.06
E param by G
redmeatqcm_v2 1.45 (1.34-1.57) 1.25 (1.18-1.33) 1.14 (1.06-1.23)
p P= 1.1e-18 P= 2.9e-13 P= 0.00032

Interaction Plot

Locuszoom

chr2_73204203_G_A

Allele freq

Stratified OR

G param by E
GG GA AA GA AA
redmeatqcm_v2=0 1 1.05 (0.99-1.12) 1.27 (1.01-1.58) 1.05 (0.99-1.12) 1.27 (1.01-1.58)
p0 P= 1 P= 0.13 P= 0.038 P= 0.13 P= 0.038
redmeatqcm_v2=1 1.31 (1.25-1.38) 1.19 (1.11-1.27) 0.99 (0.83-1.19) 0.9 (0.86-0.96) 0.76 (0.64-0.9)
p1 P= 7.7e-25 P= 1.4e-07 P= 0.95 P= 0.0003 P= 0.0017
E param by G
redmeatqcm_v2 1.31 (1.25-1.38) 1.13 (1.04-1.23) 0.79 (0.59-1.05)
p P= 7.7e-25 P= 0.0041 P= 0.1

Interaction Plot

Locuszoom

chr1_239473113_T_C

Allele freq

Stratified OR

G param by E
TT TC CC TC CC
redmeatqcm_v2=0 1 0.93 (0.88-0.99) 0.89 (0.83-0.96) 0.93 (0.88-0.99) 0.89 (0.83-0.96)
p0 P= 1 P= 0.028 P= 0.0019 P= 0.028 P= 0.0019
redmeatqcm_v2=1 1.12 (1.04-1.21) 1.18 (1.11-1.26) 1.26 (1.17-1.36) 1.05 (1-1.11) 1.12 (1.06-1.2)
p1 P= 0.0025 P= 5.7e-07 P= 8.5e-10 P= 0.049 P= 0.00025
E param by G
redmeatqcm_v2 1.12 (1.04-1.21) 1.27 (1.19-1.34) 1.42 (1.31-1.54)
p P= 0.0025 P= 5.8e-15 P= 4.3e-17

Interaction Plot

Locuszoom

2DF findings

chr8_120042899_G_T

Allele freq

GxE model by sex

sex stratified chr8_120042899_G_T_dose x redmeatqcm_v2
Dependent variable:
outcome
All (Ca=29842,Co=39635) Female (Ca=14569,Co=19615) Male (Ca=15273,Co=20020)
(1) (2) (3)
chr8_120042899_G_T_dose 1.392*** (1.268, 1.516) 1.486*** (1.309, 1.662) 1.285** (1.102, 1.468)
redmeatqcm_v2 1.270*** (1.222, 1.318) 1.260*** (1.181, 1.339) 1.297*** (1.235, 1.359)
age_ref_imp 1.000 (0.998, 1.002) 1.000 (0.998, 1.003) 0.999 (0.997, 1.002)
sex 0.975 (0.939, 1.011)
energytot_imp 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000)
chr8_120042899_G_T_dose:redmeatqcm_v2 0.808* (0.641, 0.974) 0.751* (0.473, 1.029) 0.868 (0.653, 1.084)
Constant 0.828* (0.678, 0.977) 0.698** (0.479, 0.918) 0.928 (0.721, 1.134)
Observations 69,477 34,184 35,293
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
2DF LRtest p = 3.0765e-08
2DF LRtest p = 2.2228e-06
2DF LRtest p = 9.0278e-03

GxE model by study design

study_design stratified chr8_120042899_G_T_dose x redmeatqcm_v2
Dependent variable:
outcome
All (Ca=29842,Co=39635) Cohort (Ca=12795,Co=24665) Case-Control (Ca=17047,Co=14970)
(1) (2) (3)
chr8_120042899_G_T_dose 1.392*** (1.268, 1.516) 1.465*** (1.297, 1.633) 1.317** (1.134, 1.501)
redmeatqcm_v2 1.270*** (1.222, 1.318) 1.156*** (1.090, 1.222) 1.447*** (1.375, 1.519)
age_ref_imp 1.000 (0.998, 1.002) 1.002 (0.999, 1.006) 0.999 (0.997, 1.001)
sex 0.975 (0.939, 1.011) 0.996 (0.940, 1.052) 0.944* (0.896, 0.991)
energytot_imp 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000)
chr8_120042899_G_T_dose:redmeatqcm_v2 0.808* (0.641, 0.974) 0.809 (0.586, 1.033) 0.796 (0.544, 1.047)
Constant 0.828* (0.678, 0.977) 4.538*** (4.079, 4.997) 0.872 (0.702, 1.042)
Observations 69,477 37,460 32,017
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
2DF LRtest p = 3.0765e-08
2DF LRtest p = 1.3670e-06
2DF LRtest p = 7.8400e-03

GxE model by tumor site

cancer_site_sum2 stratified chr8_120042899_G_T_dose x redmeatqcm_v2
Dependent variable:
outcome
All (Ca=29842,Co=39635) Proximal (Ca=9044,Co=39635) Distal (Ca=10519,Co=39635) Rectal (Ca=8424,Co=39635)
(1) (2) (3) (4)
chr8_120042899_G_T_dose 1.392*** (1.268, 1.516) 1.370*** (1.190, 1.550) 1.360*** (1.183, 1.536) 1.429*** (1.233, 1.626)
redmeatqcm_v2 1.270*** (1.222, 1.318) 1.350*** (1.280, 1.420) 1.243*** (1.178, 1.309) 1.293*** (1.216, 1.369)
age_ref_imp 1.000 (0.998, 1.002) 0.995*** (0.993, 0.998) 1.018*** (1.016, 1.021) 0.985*** (0.983, 0.988)
sex 0.975 (0.939, 1.011) 1.006 (0.953, 1.060) 0.782*** (0.730, 0.834) 1.235*** (1.180, 1.291)
energytot_imp 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000) 1.000 (1.000, 1.000)
chr8_120042899_G_T_dose:redmeatqcm_v2 0.808* (0.641, 0.974) 0.868 (0.636, 1.100) 0.795 (0.562, 1.027) 0.706* (0.422, 0.989)
Constant 0.828* (0.678, 0.977) 0.467*** (0.261, 0.673) 0.079*** (-0.144, 0.302) 0.547*** (0.327, 0.766)
Observations 69,477 48,679 50,154 48,059
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
2DF LRtest p = 3.0765e-08
2DF LRtest p = 1.4735e-04
2DF LRtest p = 1.5193e-03
2DF LRtest p = 1.5964e-03

Stratified OR

G param by E
GG GT TT GT TT
redmeatqcm_v2=0 1 1.4 (1.23-1.59) 1.68 (0.55-5.1) 1.4 (1.23-1.59) 1.68 (0.55-5.1)
p0 P= 1 P= 3.3e-07 P= 0.36 P= 3.3e-07 P= 0.36
redmeatqcm_v2=1 1.27 (1.21-1.33) 1.43 (1.28-1.6) 1.48 (0.74-2.96) 1.13 (1.01-1.25) 1.16 (0.58-2.33)
p1 P= 2.1e-22 P= 2.1e-10 P= 0.27 P= 0.026 P= 0.67
E param by G
redmeatqcm_v2 1.27 (1.21-1.33) 1.03 (0.86-1.22) 0.88 (0.26-3.02)
p P= 2.1e-22 P= 0.77 P= 0.84

Interaction Plot

Locuszoom

Func Annot

chr8_122247679_C_G

Allele freq

GxE model by sex

sex stratified chr8_122247679_C_G_dose x redmeatqcm_v2
Dependent variable:
outcome
All (Ca=29842,Co=39635) Female (Ca=14569,Co=19615) Male (Ca=15273,Co=20020)
(1) (2) (3)
chr8_122247679_C_G_dose 1.033 (0.994, 1.072) 1.037 (0.981, 1.094) 1.023 (0.968, 1.078)
redmeatqcm_v2 1.372*** (1.313, 1.432) 1.338*** (1.240, 1.437) 1.412*** (1.336, 1.488)
age_ref_imp 1.000 (0.998, 1.002) 1.000 (0.998, 1.003) 0.999 (0.997, 1.002)
sex 0.974 (0.937, 1.010)
energytot_imp 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000)
chr8_122247679_C_G_dose:redmeatqcm_v2 0.876*** (0.823, 0.929) 0.892* (0.801, 0.983) 0.872*** (0.805, 0.938)
Constant 0.824* (0.672, 0.976) 0.696** (0.474, 0.919) 0.924 (0.715, 1.134)
Observations 69,477 34,184 35,293
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
2DF LRtest p = 1.2062e-08
2DF LRtest p = 2.5094e-02
2DF LRtest p = 1.4500e-07

GxE model by study design

study_design stratified chr8_122247679_C_G_dose x redmeatqcm_v2
Dependent variable:
outcome
All (Ca=29842,Co=39635) Cohort (Ca=12795,Co=24665) Case-Control (Ca=17047,Co=14970)
(1) (2) (3)
chr8_122247679_C_G_dose 1.033 (0.994, 1.072) 1.047 (0.990, 1.103) 1.026 (0.972, 1.079)
redmeatqcm_v2 1.372*** (1.313, 1.432) 1.240*** (1.159, 1.321) 1.585*** (1.497, 1.674)
age_ref_imp 1.000 (0.998, 1.002) 1.002 (0.999, 1.006) 0.999 (0.997, 1.001)
sex 0.974 (0.937, 1.010) 0.995 (0.939, 1.051) 0.943* (0.895, 0.990)
energytot_imp 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000)
chr8_122247679_C_G_dose:redmeatqcm_v2 0.876*** (0.823, 0.929) 0.886** (0.814, 0.959) 0.858*** (0.779, 0.936)
Constant 0.824* (0.672, 0.976) 4.541*** (4.080, 5.001) 0.871 (0.698, 1.044)
Observations 69,477 37,460 32,017
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
2DF LRtest p = 1.2062e-08
2DF LRtest p = 1.3258e-03
2DF LRtest p = 2.4918e-06

GxE model by tumor site

cancer_site_sum2 stratified chr8_122247679_C_G_dose x redmeatqcm_v2
Dependent variable:
outcome
All (Ca=29842,Co=39635) Proximal (Ca=9044,Co=39635) Distal (Ca=10519,Co=39635) Rectal (Ca=8424,Co=39635)
(1) (2) (3) (4)
chr8_122247679_C_G_dose 1.033 (0.994, 1.072) 1.047 (0.990, 1.105) 1.038 (0.983, 1.093) 1.005 (0.944, 1.066)
redmeatqcm_v2 1.372*** (1.313, 1.432) 1.497*** (1.412, 1.582) 1.331*** (1.250, 1.412) 1.358*** (1.263, 1.452)
age_ref_imp 1.000 (0.998, 1.002) 0.995*** (0.993, 0.998) 1.018*** (1.016, 1.021) 0.985*** (0.983, 0.988)
sex 0.974 (0.937, 1.010) 1.005 (0.952, 1.058) 0.782*** (0.730, 0.834) 1.235*** (1.179, 1.290)
energytot_imp 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000) 1.000 (1.000, 1.000)
chr8_122247679_C_G_dose:redmeatqcm_v2 0.876*** (0.823, 0.929) 0.846*** (0.769, 0.923) 0.887** (0.814, 0.960) 0.907* (0.823, 0.992)
Constant 0.824* (0.672, 0.976) 0.461*** (0.252, 0.670) 0.079*** (-0.147, 0.305) 0.555*** (0.331, 0.778)
Observations 69,477 48,679 50,154 48,059
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
2DF LRtest p = 1.2062e-08
2DF LRtest p = 1.8136e-06
2DF LRtest p = 8.6551e-04
2DF LRtest p = 2.3498e-03

Stratified OR

G param by E
CC CG GG CG GG
redmeatqcm_v2=0 1 1.03 (0.98-1.09) 1.07 (0.98-1.16) 1.03 (0.98-1.09) 1.07 (0.98-1.16)
p0 P= 1 P= 0.24 P= 0.14 P= 0.24 P= 0.14
redmeatqcm_v2=1 1.38 (1.29-1.46) 1.24 (1.16-1.31) 1.14 (1.05-1.24) 0.9 (0.86-0.94) 0.83 (0.77-0.89)
p1 P= 4.1e-24 P= 4.7e-12 P= 0.0023 P= 6e-06 P= 3.8e-07
E param by G
redmeatqcm_v2 1.38 (1.29-1.46) 1.2 (1.12-1.27) 1.07 (0.95-1.19)
p P= 4.1e-24 P= 1.5e-08 P= 0.25

Interaction Plot

Locuszoom

Func Annot

chr10_86469912_G_A

Allele freq

GxE model by sex

sex stratified chr10_86469912_G_A_dose x redmeatqcm_v2
Dependent variable:
outcome
All (Ca=29842,Co=39635) Female (Ca=14569,Co=19615) Male (Ca=15273,Co=20020)
(1) (2) (3)
chr10_86469912_G_A_dose 1.504*** (1.350, 1.658) 1.515*** (1.293, 1.738) 1.581*** (1.360, 1.801)
redmeatqcm_v2 1.266*** (1.218, 1.313) 1.256*** (1.177, 1.334) 1.296*** (1.234, 1.357)
age_ref_imp 1.000 (0.998, 1.002) 1.000 (0.998, 1.003) 0.999 (0.997, 1.002)
sex 0.973 (0.937, 1.009)
energytot_imp 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000)
chr10_86469912_G_A_dose:redmeatqcm_v2 0.774* (0.556, 0.991) 0.653* (0.284, 1.023) 0.805 (0.529, 1.081)
Constant 0.828* (0.679, 0.978) 0.703** (0.483, 0.922) 0.921 (0.714, 1.127)
Observations 69,477 34,184 35,293
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
2DF LRtest p = 3.6599e-08
2DF LRtest p = 7.3955e-04
2DF LRtest p = 8.8525e-06

GxE model by study design

study_design stratified chr10_86469912_G_A_dose x redmeatqcm_v2
Dependent variable:
outcome
All (Ca=29842,Co=39635) Cohort (Ca=12795,Co=24665) Case-Control (Ca=17047,Co=14970)
(1) (2) (3)
chr10_86469912_G_A_dose 1.504*** (1.350, 1.658) 1.410** (1.196, 1.624) 1.595*** (1.371, 1.819)
redmeatqcm_v2 1.266*** (1.218, 1.313) 1.150*** (1.084, 1.215) 1.443*** (1.372, 1.514)
age_ref_imp 1.000 (0.998, 1.002) 1.003 (0.999, 1.006) 0.999 (0.997, 1.001)
sex 0.973 (0.937, 1.009) 0.994 (0.938, 1.050) 0.943* (0.896, 0.990)
energytot_imp 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000)
chr10_86469912_G_A_dose:redmeatqcm_v2 0.774* (0.556, 0.991) 0.858 (0.568, 1.148) 0.692* (0.360, 1.024)
Constant 0.828* (0.679, 0.978) 4.558*** (4.099, 5.017) 0.871 (0.702, 1.041)
Observations 69,477 37,460 32,017
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
2DF LRtest p = 3.6599e-08
2DF LRtest p = 5.5830e-04
2DF LRtest p = 6.2346e-05

GxE model by tumor site

cancer_site_sum2 stratified chr10_86469912_G_A_dose x redmeatqcm_v2
Dependent variable:
outcome
All (Ca=29842,Co=39635) Proximal (Ca=9044,Co=39635) Distal (Ca=10519,Co=39635) Rectal (Ca=8424,Co=39635)
(1) (2) (3) (4)
chr10_86469912_G_A_dose 1.504*** (1.350, 1.658) 1.508*** (1.282, 1.733) 1.527*** (1.316, 1.738) 1.647*** (1.405, 1.888)
redmeatqcm_v2 1.266*** (1.218, 1.313) 1.349*** (1.280, 1.418) 1.237*** (1.172, 1.302) 1.286*** (1.210, 1.362)
age_ref_imp 1.000 (0.998, 1.002) 0.995*** (0.993, 0.998) 1.018*** (1.016, 1.021) 0.985*** (0.983, 0.988)
sex 0.973 (0.937, 1.009) 1.005 (0.952, 1.059) 0.781*** (0.729, 0.833) 1.235*** (1.180, 1.291)
energytot_imp 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000) 1.000 (1.000, 1.000)
chr10_86469912_G_A_dose:redmeatqcm_v2 0.774* (0.556, 0.991) 0.774 (0.458, 1.090) 0.799 (0.505, 1.093) 0.641* (0.281, 1.001)
Constant 0.828* (0.679, 0.978) 0.468*** (0.262, 0.674) 0.079*** (-0.144, 0.303) 0.547*** (0.328, 0.767)
Observations 69,477 48,679 50,154 48,059
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
2DF LRtest p = 3.6599e-08
2DF LRtest p = 4.4459e-04
2DF LRtest p = 3.4325e-05
2DF LRtest p = 2.0981e-04

Stratified OR

G param by E
GG GA AA GA AA
redmeatqcm_v2=0 1 1.54 (1.31-1.8) 0.98 (0.25-3.84) 1.54 (1.31-1.8) 0.98 (0.25-3.84)
p0 P= 1 P= 9.4e-08 P= 0.97 P= 9.4e-08 P= 0.97
redmeatqcm_v2=1 1.27 (1.21-1.33) 1.47 (1.27-1.7) 2.06 (0.49-8.72) 1.16 (1.01-1.34) 1.63 (0.39-6.88)
p1 P= 3.9e-22 P= 1.7e-07 P= 0.32 P= 0.038 P= 0.51
E param by G
redmeatqcm_v2 1.27 (1.21-1.33) 0.95 (0.77-1.19) 2.11 (0.24-18.83)
p P= 3.9e-22 P= 0.68 P= 0.5

Interaction Plot

Locuszoom

Func Annot

3DF findings

(same locus as 2DF) – see above

Two-step findings

chr18_46453754_C_T

Allele freq

GxE model by sex

sex stratified chr18_46453754_C_T_dose x redmeatqcm_v2
Dependent variable:
outcome
All (Ca=29842,Co=39635) Female (Ca=14569,Co=19615) Male (Ca=15273,Co=20020)
(1) (2) (3)
chr18_46453754_C_T_dose 0.820*** (0.777, 0.863) 0.811*** (0.748, 0.874) 0.827*** (0.766, 0.889)
redmeatqcm_v2 1.180*** (1.124, 1.237) 1.154** (1.060, 1.247) 1.217*** (1.145, 1.289)
age_ref_imp 1.000 (0.998, 1.002) 1.000 (0.998, 1.003) 1.000 (0.997, 1.002)
sex 0.973 (0.937, 1.009)
energytot_imp 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000)
chr18_46453754_C_T_dose:redmeatqcm_v2 1.129*** (1.070, 1.188) 1.149** (1.048, 1.249) 1.118** (1.044, 1.192)
Constant 0.926 (0.775, 1.077) 0.794* (0.572, 1.016) 1.022 (0.814, 1.231)
Observations 69,477 34,184 35,293
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 4.8149e-05
GxE term LRtest p = 6.7079e-03
GxE term LRtest p = 3.0407e-03

GxE model by study design

study_design stratified chr18_46453754_C_T_dose x redmeatqcm_v2
Dependent variable:
outcome
All (Ca=29842,Co=39635) Cohort (Ca=12795,Co=24665) Case-Control (Ca=17047,Co=14970)
(1) (2) (3)
chr18_46453754_C_T_dose 0.820*** (0.777, 0.863) 0.834*** (0.772, 0.896) 0.807*** (0.746, 0.868)
redmeatqcm_v2 1.180*** (1.124, 1.237) 1.082* (1.005, 1.159) 1.333*** (1.250, 1.416)
age_ref_imp 1.000 (0.998, 1.002) 1.002 (0.999, 1.006) 0.999 (0.997, 1.002)
sex 0.973 (0.937, 1.009) 0.995 (0.939, 1.052) 0.942* (0.894, 0.989)
energytot_imp 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000)
chr18_46453754_C_T_dose:redmeatqcm_v2 1.129*** (1.070, 1.188) 1.115** (1.036, 1.194) 1.147** (1.059, 1.235)
Constant 0.926 (0.775, 1.077) 5.085*** (4.625, 5.546) 0.981 (0.809, 1.153)
Observations 69,477 37,460 32,017
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 4.8149e-05
GxE term LRtest p = 6.9183e-03
GxE term LRtest p = 2.3280e-03

GxE model by tumor site

cancer_site_sum2 stratified chr18_46453754_C_T_dose x redmeatqcm_v2
Dependent variable:
outcome
All (Ca=29842,Co=39635) Proximal (Ca=9044,Co=39635) Distal (Ca=10519,Co=39635) Rectal (Ca=8424,Co=39635)
(1) (2) (3) (4)
chr18_46453754_C_T_dose 0.820*** (0.777, 0.863) 0.784*** (0.719, 0.848) 0.844*** (0.783, 0.906) 0.824*** (0.756, 0.892)
redmeatqcm_v2 1.180*** (1.124, 1.237) 1.259*** (1.179, 1.340) 1.144*** (1.067, 1.221) 1.207*** (1.118, 1.296)
age_ref_imp 1.000 (0.998, 1.002) 0.995*** (0.993, 0.998) 1.018*** (1.016, 1.021) 0.985*** (0.983, 0.988)
sex 0.973 (0.937, 1.009) 1.004 (0.951, 1.057) 0.781*** (0.729, 0.833) 1.233*** (1.178, 1.289)
energytot_imp 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000) 1.000 (1.000, 1.000)
chr18_46453754_C_T_dose:redmeatqcm_v2 1.129*** (1.070, 1.188) 1.131** (1.046, 1.216) 1.146*** (1.066, 1.226) 1.103* (1.009, 1.197)
Constant 0.926 (0.775, 1.077) 0.533*** (0.325, 0.741) 0.088*** (-0.138, 0.313) 0.612*** (0.391, 0.834)
Observations 69,477 48,679 50,154 48,059
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
GxE term LRtest p = 4.8149e-05
GxE term LRtest p = 4.5998e-03
GxE term LRtest p = 8.7023e-04
GxE term LRtest p = 4.1705e-02

Stratified OR

G param by E
CC CT TT CT TT
redmeatqcm_v2=0 1 0.83 (0.79-0.88) 0.65 (0.58-0.73) 0.83 (0.79-0.88) 0.65 (0.58-0.73)
p0 P= 1 P= 2e-10 P= 8.1e-14 P= 2e-10 P= 8.1e-14
redmeatqcm_v2=1 1.17 (1.11-1.24) 1.13 (1.06-1.19) 0.94 (0.85-1.04) 0.96 (0.91-1.01) 0.8 (0.73-0.88)
p1 P= 4.2e-08 P= 0.0001 P= 0.25 P= 0.08 P= 3.9e-06
E param by G
redmeatqcm_v2 1.17 (1.11-1.24) 1.35 (1.26-1.44) 1.46 (1.26-1.68)
p P= 4.2e-08 P= 9.5e-19 P= 5.2e-07

Interaction Plot

Locuszoom

Func Annot

E|G finding (combined case-control sample)

(SNP associated with meat intake)

chr19_49232226_G_A

Allele freq

Locuszoom

Func Annot