Suggestive GxE (P < 5e-6)
chr17_71354811_G_A
Allele freq

Stratified OR
|
|
G param by E
|
|
|
GG
|
GA
|
AA
|
GA
|
AA
|
|
redmeatqcm_v2=0
|
1
|
0.74 (0.65-0.85)
|
1.37 (0.52-3.6)
|
0.74 (0.65-0.85)
|
1.37 (0.52-3.6)
|
|
p0
|
P= 1
|
P= 9e-06
|
P= 0.53
|
P= 9e-06
|
P= 0.53
|
|
redmeatqcm_v2=1
|
1.23 (1.17-1.29)
|
1.57 (1.38-1.79)
|
2.66 (0.92-7.72)
|
1.28 (1.12-1.45)
|
2.17 (0.75-6.27)
|
|
p1
|
P= 3e-17
|
P= 2.3e-11
|
P= 0.071
|
P= 0.00021
|
P= 0.15
|
|
E param by G
|
|
redmeatqcm_v2
|
1.23 (1.17-1.29)
|
2.12 (1.74-2.58)
|
1.95 (0.4-9.48)
|
|
|
|
p
|
P= 3e-17
|
P= 8.6e-14
|
P= 0.41
|
|
|
Interaction Plot

Locuszoom

chr9_120653523_T_G
Allele freq

Stratified OR
|
|
G param by E
|
|
|
TT
|
TG
|
GG
|
TG
|
GG
|
|
redmeatqcm_v2=0
|
1
|
1.2 (1.07-1.35)
|
1.77 (0.83-3.79)
|
1.2 (1.07-1.35)
|
1.77 (0.83-3.79)
|
|
p0
|
P= 1
|
P= 0.0017
|
P= 0.14
|
P= 0.0017
|
P= 0.14
|
|
redmeatqcm_v2=1
|
1.29 (1.23-1.36)
|
1.08 (0.98-1.18)
|
0.96 (0.51-1.81)
|
0.83 (0.76-0.91)
|
0.74 (0.39-1.39)
|
|
p1
|
P= 4.5e-25
|
P= 0.13
|
P= 0.9
|
P= 5.8e-05
|
P= 0.35
|
|
E param by G
|
|
redmeatqcm_v2
|
1.29 (1.23-1.36)
|
0.89 (0.77-1.04)
|
0.54 (0.19-1.56)
|
|
|
|
p
|
P= 4.5e-25
|
P= 0.14
|
P= 0.26
|
|
|
Interaction Plot

Locuszoom

chr4_31160820_G_A
Allele freq

Stratified OR
|
|
G param by E
|
|
|
GG
|
GA
|
AA
|
GA
|
AA
|
|
redmeatqcm_v2=0
|
1
|
0.8 (0.72-0.9)
|
0.48 (0.22-1.05)
|
0.8 (0.72-0.9)
|
0.48 (0.22-1.05)
|
|
p0
|
P= 1
|
P= 0.00011
|
P= 0.066
|
P= 0.00011
|
P= 0.066
|
|
redmeatqcm_v2=1
|
1.23 (1.17-1.29)
|
1.49 (1.33-1.66)
|
0.81 (0.35-1.88)
|
1.21 (1.09-1.35)
|
0.66 (0.29-1.53)
|
|
p1
|
P= 1.2e-16
|
P= 9.4e-13
|
P= 0.63
|
P= 0.00031
|
P= 0.34
|
|
E param by G
|
|
redmeatqcm_v2
|
1.23 (1.17-1.29)
|
1.85 (1.58-2.17)
|
1.69 (0.51-5.61)
|
|
|
|
p
|
P= 1.2e-16
|
P= 5.2e-14
|
P= 0.39
|
|
|
Interaction Plot

Locuszoom

chr9_120290042_A_G
Allele freq

Stratified OR
|
|
G param by E
|
|
|
AA
|
AG
|
GG
|
AG
|
GG
|
|
redmeatqcm_v2=0
|
1
|
1.25 (1.09-1.42)
|
1.31 (0.43-3.98)
|
1.25 (1.09-1.42)
|
1.31 (0.43-3.98)
|
|
p0
|
P= 1
|
P= 0.0011
|
P= 0.63
|
P= 0.0011
|
P= 0.63
|
|
redmeatqcm_v2=1
|
1.29 (1.22-1.35)
|
1.07 (0.97-1.2)
|
0.5 (0.2-1.25)
|
0.84 (0.76-0.93)
|
0.39 (0.15-0.97)
|
|
p1
|
P= 2.2e-24
|
P= 0.19
|
P= 0.14
|
P= 0.00055
|
P= 0.044
|
|
E param by G
|
|
redmeatqcm_v2
|
1.29 (1.22-1.35)
|
0.86 (0.73-1.02)
|
0.38 (0.09-1.68)
|
|
|
|
p
|
P= 2.2e-24
|
P= 0.084
|
P= 0.2
|
|
|
Interaction Plot

Locuszoom

chr8_122247679_C_G
Allele freq

Stratified OR
|
|
G param by E
|
|
|
CC
|
CG
|
GG
|
CG
|
GG
|
|
redmeatqcm_v2=0
|
1
|
1.03 (0.98-1.09)
|
1.07 (0.98-1.16)
|
1.03 (0.98-1.09)
|
1.07 (0.98-1.16)
|
|
p0
|
P= 1
|
P= 0.24
|
P= 0.14
|
P= 0.24
|
P= 0.14
|
|
redmeatqcm_v2=1
|
1.38 (1.29-1.46)
|
1.24 (1.16-1.31)
|
1.14 (1.05-1.24)
|
0.9 (0.86-0.94)
|
0.83 (0.77-0.89)
|
|
p1
|
P= 4.1e-24
|
P= 4.7e-12
|
P= 0.0023
|
P= 6e-06
|
P= 3.8e-07
|
|
E param by G
|
|
redmeatqcm_v2
|
1.38 (1.29-1.46)
|
1.2 (1.12-1.27)
|
1.07 (0.95-1.19)
|
|
|
|
p
|
P= 4.1e-24
|
P= 1.5e-08
|
P= 0.25
|
|
|
Interaction Plot

Locuszoom

chr1_21495668_G_T
Allele freq

Stratified OR
|
|
G param by E
|
|
|
GG
|
GT
|
TT
|
GT
|
TT
|
|
redmeatqcm_v2=0
|
1
|
1.16 (1.07-1.26)
|
1.61 (1.07-2.44)
|
1.16 (1.07-1.26)
|
1.61 (1.07-2.44)
|
|
p0
|
P= 1
|
P= 0.00048
|
P= 0.023
|
P= 0.00048
|
P= 0.023
|
|
redmeatqcm_v2=1
|
1.3 (1.23-1.36)
|
1.16 (1.07-1.26)
|
1.11 (0.76-1.62)
|
0.9 (0.83-0.96)
|
0.86 (0.59-1.25)
|
|
p1
|
P= 3.7e-25
|
P= 0.00018
|
P= 0.59
|
P= 0.0031
|
P= 0.42
|
|
E param by G
|
|
redmeatqcm_v2
|
1.3 (1.23-1.36)
|
1 (0.9-1.12)
|
0.69 (0.38-1.24)
|
|
|
|
p
|
P= 3.7e-25
|
P= 0.94
|
P= 0.21
|
|
|
Interaction Plot

Locuszoom

chr3_29246192_C_T
Allele freq

Stratified OR
|
|
G param by E
|
|
|
CC
|
CT
|
TT
|
CT
|
TT
|
|
redmeatqcm_v2=0
|
1
|
0.81 (0.72-0.92)
|
0.38 (0.15-0.98)
|
0.81 (0.72-0.92)
|
0.38 (0.15-0.98)
|
|
p0
|
P= 1
|
P= 0.00071
|
P= 0.046
|
P= 0.00071
|
P= 0.046
|
|
redmeatqcm_v2=1
|
1.23 (1.18-1.3)
|
1.53 (1.36-1.72)
|
0.84 (0.31-2.26)
|
1.24 (1.1-1.39)
|
0.68 (0.25-1.83)
|
|
p1
|
P= 8e-18
|
P= 2.6e-12
|
P= 0.73
|
P= 0.00025
|
P= 0.44
|
|
E param by G
|
|
redmeatqcm_v2
|
1.23 (1.18-1.3)
|
1.88 (1.58-2.24)
|
2.21 (0.46-10.48)
|
|
|
|
p
|
P= 8e-18
|
P= 1.6e-12
|
P= 0.32
|
|
|
Interaction Plot

Locuszoom

chr1_21209766_T_A
Allele freq

Stratified OR
|
|
G param by E
|
|
|
TT
|
TA
|
AA
|
TA
|
AA
|
|
redmeatqcm_v2=0
|
1
|
1.16 (1.07-1.26)
|
1.79 (1.18-2.71)
|
1.16 (1.07-1.26)
|
1.79 (1.18-2.71)
|
|
p0
|
P= 1
|
P= 0.0005
|
P= 0.006
|
P= 0.0005
|
P= 0.006
|
|
redmeatqcm_v2=1
|
1.3 (1.23-1.36)
|
1.18 (1.09-1.27)
|
1.11 (0.76-1.62)
|
0.91 (0.84-0.97)
|
0.86 (0.59-1.25)
|
|
p1
|
P= 5.2e-25
|
P= 6.2e-05
|
P= 0.58
|
P= 0.0076
|
P= 0.42
|
|
E param by G
|
|
redmeatqcm_v2
|
1.3 (1.23-1.36)
|
1.02 (0.91-1.14)
|
0.62 (0.35-1.12)
|
|
|
|
p
|
P= 5.2e-25
|
P= 0.79
|
P= 0.11
|
|
|
Interaction Plot

Locuszoom

chr15_100002029_C_T
Allele freq

Stratified OR
|
|
G param by E
|
|
|
CC
|
CT
|
TT
|
CT
|
TT
|
|
redmeatqcm_v2=0
|
1
|
1.01 (0.94-1.09)
|
1.13 (1.04-1.22)
|
1.01 (0.94-1.09)
|
1.13 (1.04-1.22)
|
|
p0
|
P= 1
|
P= 0.77
|
P= 0.0023
|
P= 0.77
|
P= 0.0023
|
|
redmeatqcm_v2=1
|
1.4 (1.27-1.55)
|
1.35 (1.25-1.46)
|
1.27 (1.17-1.38)
|
0.96 (0.9-1.03)
|
0.9 (0.85-0.97)
|
|
p1
|
P= 1.1e-11
|
P= 3.1e-13
|
P= 1.3e-08
|
P= 0.27
|
P= 0.004
|
|
E param by G
|
|
redmeatqcm_v2
|
1.4 (1.27-1.55)
|
1.34 (1.26-1.42)
|
1.12 (1.05-1.2)
|
|
|
|
p
|
P= 1.1e-11
|
P= 9.8e-21
|
P= 0.00047
|
|
|
Interaction Plot

Locuszoom

chr8_112374447_C_T
Allele freq

Stratified OR
|
|
G param by E
|
|
|
CC
|
CT
|
TT
|
CT
|
TT
|
|
redmeatqcm_v2=0
|
1
|
1.06 (0.96-1.17)
|
1.14 (1.03-1.26)
|
1.06 (0.96-1.17)
|
1.14 (1.03-1.26)
|
|
p0
|
P= 1
|
P= 0.28
|
P= 0.0085
|
P= 0.28
|
P= 0.0085
|
|
redmeatqcm_v2=1
|
1.48 (1.3-1.69)
|
1.43 (1.28-1.58)
|
1.33 (1.2-1.47)
|
0.96 (0.88-1.05)
|
0.89 (0.82-0.97)
|
|
p1
|
P= 2.6e-09
|
P= 2.4e-11
|
P= 7.7e-08
|
P= 0.36
|
P= 0.0086
|
|
E param by G
|
|
redmeatqcm_v2
|
1.48 (1.3-1.69)
|
1.35 (1.26-1.44)
|
1.16 (1.09-1.23)
|
|
|
|
p
|
P= 2.6e-09
|
P= 1.9e-19
|
P= 8.8e-07
|
|
|
Interaction Plot

Locuszoom

chr18_21029284_C_T
Allele freq

Stratified OR
|
|
G param by E
|
|
|
CC
|
CT
|
TT
|
CT
|
TT
|
|
redmeatqcm_v2=0
|
1
|
0.76 (0.65-0.88)
|
0.29 (0.05-1.66)
|
0.76 (0.65-0.88)
|
0.29 (0.05-1.66)
|
|
p0
|
P= 1
|
P= 0.00026
|
P= 0.16
|
P= 0.00026
|
P= 0.16
|
|
redmeatqcm_v2=1
|
1.24 (1.18-1.3)
|
1.53 (1.33-1.76)
|
2.42 (0.51-11.43)
|
1.23 (1.08-1.41)
|
1.96 (0.41-9.23)
|
|
p1
|
P= 2.2e-18
|
P= 2.8e-09
|
P= 0.26
|
P= 0.0024
|
P= 0.4
|
|
E param by G
|
|
redmeatqcm_v2
|
1.24 (1.18-1.3)
|
2.02 (1.63-2.5)
|
8.37 (0.5-141.39)
|
|
|
|
p
|
P= 2.2e-18
|
P= 1.6e-10
|
P= 0.14
|
|
|
Interaction Plot

Locuszoom

chr20_51479759_G_T
Allele freq

Stratified OR
|
|
G param by E
|
|
|
GG
|
GT
|
TT
|
GT
|
TT
|
|
redmeatqcm_v2=0
|
1
|
1.4 (1.15-1.7)
|
1.14 (0.1-12.81)
|
1.4 (1.15-1.7)
|
1.14 (0.1-12.81)
|
|
p0
|
P= 1
|
P= 0.00065
|
P= 0.92
|
P= 0.00065
|
P= 0.92
|
|
redmeatqcm_v2=1
|
1.28 (1.22-1.34)
|
0.96 (0.82-1.13)
|
1.43 (0.32-6.27)
|
0.75 (0.64-0.88)
|
1.12 (0.25-4.91)
|
|
p1
|
P= 1.2e-23
|
P= 0.63
|
P= 0.64
|
P= 0.0004
|
P= 0.88
|
|
E param by G
|
|
redmeatqcm_v2
|
1.28 (1.22-1.34)
|
0.69 (0.53-0.89)
|
1.25 (0.09-18.01)
|
|
|
|
p
|
P= 1.2e-23
|
P= 0.004
|
P= 0.87
|
|
|
Interaction Plot

Locuszoom

chr2_42324419_T_A
Allele freq

Stratified OR
|
|
G param by E
|
|
|
TT
|
TA
|
AA
|
TA
|
AA
|
|
redmeatqcm_v2=0
|
1
|
1.08 (1.01-1.15)
|
1.14 (1.06-1.23)
|
1.08 (1.01-1.15)
|
1.14 (1.06-1.23)
|
|
p0
|
P= 1
|
P= 0.015
|
P= 0.00045
|
P= 0.015
|
P= 0.00045
|
|
redmeatqcm_v2=1
|
1.39 (1.3-1.5)
|
1.35 (1.27-1.45)
|
1.25 (1.16-1.35)
|
0.97 (0.92-1.02)
|
0.9 (0.84-0.96)
|
|
p1
|
P= 4.3e-19
|
P= 1.9e-19
|
P= 5.9e-09
|
P= 0.25
|
P= 0.00072
|
|
E param by G
|
|
redmeatqcm_v2
|
1.39 (1.3-1.5)
|
1.25 (1.18-1.33)
|
1.09 (1.01-1.19)
|
|
|
|
p
|
P= 4.3e-19
|
P= 9.4e-14
|
P= 0.034
|
|
|
Interaction Plot

Locuszoom

chr10_29013189_C_T
Allele freq

Stratified OR
|
|
G param by E
|
|
|
CC
|
CT
|
TT
|
CT
|
TT
|
|
redmeatqcm_v2=0
|
1
|
0.89 (0.83-0.95)
|
0.81 (0.67-0.98)
|
0.89 (0.83-0.95)
|
0.81 (0.67-0.98)
|
|
p0
|
P= 1
|
P= 0.00022
|
P= 0.028
|
P= 0.00022
|
P= 0.028
|
|
redmeatqcm_v2=1
|
1.19 (1.13-1.26)
|
1.28 (1.2-1.37)
|
1.26 (1.07-1.49)
|
1.07 (1.02-1.13)
|
1.06 (0.9-1.25)
|
|
p1
|
P= 3.7e-11
|
P= 3e-14
|
P= 0.0063
|
P= 0.0096
|
P= 0.5
|
|
E param by G
|
|
redmeatqcm_v2
|
1.19 (1.13-1.26)
|
1.44 (1.33-1.56)
|
1.56 (1.21-2.02)
|
|
|
|
p
|
P= 3.7e-11
|
P= 6.9e-19
|
P= 0.00071
|
|
|
Interaction Plot

Locuszoom

chr13_62734417_A_G
Allele freq

Stratified OR
|
|
G param by E
|
|
|
AA
|
AG
|
GG
|
AG
|
GG
|
|
redmeatqcm_v2=0
|
1
|
0.9 (0.84-0.96)
|
0.8 (0.62-1.04)
|
0.9 (0.84-0.96)
|
0.8 (0.62-1.04)
|
|
p0
|
P= 1
|
P= 0.002
|
P= 0.094
|
P= 0.002
|
P= 0.094
|
|
redmeatqcm_v2=1
|
1.21 (1.15-1.27)
|
1.33 (1.25-1.43)
|
1.3 (1.04-1.62)
|
1.11 (1.04-1.17)
|
1.08 (0.87-1.34)
|
|
p1
|
P= 3.9e-13
|
P= 4.7e-17
|
P= 0.019
|
P= 0.00058
|
P= 0.5
|
|
E param by G
|
|
redmeatqcm_v2
|
1.21 (1.15-1.27)
|
1.48 (1.36-1.62)
|
1.61 (1.14-2.29)
|
|
|
|
p
|
P= 3.9e-13
|
P= 3.9e-18
|
P= 0.0073
|
|
|
Interaction Plot

Locuszoom

chr1_41466550_T_A
Allele freq

Stratified OR
|
|
G param by E
|
|
|
TT
|
TA
|
AA
|
TA
|
AA
|
|
redmeatqcm_v2=0
|
1
|
1.1 (1.04-1.17)
|
1.12 (1.04-1.21)
|
1.1 (1.04-1.17)
|
1.12 (1.04-1.21)
|
|
p0
|
P= 1
|
P= 0.0011
|
P= 0.0044
|
P= 0.0011
|
P= 0.0044
|
|
redmeatqcm_v2=1
|
1.41 (1.32-1.51)
|
1.33 (1.25-1.42)
|
1.26 (1.17-1.36)
|
0.94 (0.9-0.99)
|
0.89 (0.84-0.95)
|
|
p1
|
P= 1.9e-22
|
P= 6.7e-19
|
P= 2.6e-09
|
P= 0.022
|
P= 0.00064
|
|
E param by G
|
|
redmeatqcm_v2
|
1.41 (1.32-1.51)
|
1.21 (1.14-1.28)
|
1.13 (1.03-1.23)
|
|
|
|
p
|
P= 1.9e-22
|
P= 7.3e-10
|
P= 0.0092
|
|
|
Interaction Plot

Locuszoom

chr3_27633795_G_A
Allele freq

Stratified OR
|
|
G param by E
|
|
|
GG
|
GA
|
AA
|
GA
|
AA
|
|
redmeatqcm_v2=0
|
1
|
1.13 (1.06-1.2)
|
1.19 (1.11-1.28)
|
1.13 (1.06-1.2)
|
1.19 (1.11-1.28)
|
|
p0
|
P= 1
|
P= 0.00036
|
P= 2.5e-06
|
P= 0.00036
|
P= 2.5e-06
|
|
redmeatqcm_v2=1
|
1.45 (1.34-1.57)
|
1.41 (1.31-1.51)
|
1.37 (1.27-1.47)
|
0.97 (0.92-1.03)
|
0.94 (0.88-1)
|
|
p1
|
P= 1.1e-18
|
P= 3.3e-21
|
P= 7.5e-16
|
P= 0.32
|
P= 0.06
|
|
E param by G
|
|
redmeatqcm_v2
|
1.45 (1.34-1.57)
|
1.25 (1.18-1.33)
|
1.14 (1.06-1.23)
|
|
|
|
p
|
P= 1.1e-18
|
P= 2.9e-13
|
P= 0.00032
|
|
|
Interaction Plot

Locuszoom

chr2_73204203_G_A
Allele freq

Stratified OR
|
|
G param by E
|
|
|
GG
|
GA
|
AA
|
GA
|
AA
|
|
redmeatqcm_v2=0
|
1
|
1.05 (0.99-1.12)
|
1.27 (1.01-1.58)
|
1.05 (0.99-1.12)
|
1.27 (1.01-1.58)
|
|
p0
|
P= 1
|
P= 0.13
|
P= 0.038
|
P= 0.13
|
P= 0.038
|
|
redmeatqcm_v2=1
|
1.31 (1.25-1.38)
|
1.19 (1.11-1.27)
|
0.99 (0.83-1.19)
|
0.9 (0.86-0.96)
|
0.76 (0.64-0.9)
|
|
p1
|
P= 7.7e-25
|
P= 1.4e-07
|
P= 0.95
|
P= 0.0003
|
P= 0.0017
|
|
E param by G
|
|
redmeatqcm_v2
|
1.31 (1.25-1.38)
|
1.13 (1.04-1.23)
|
0.79 (0.59-1.05)
|
|
|
|
p
|
P= 7.7e-25
|
P= 0.0041
|
P= 0.1
|
|
|
Interaction Plot

Locuszoom

chr1_239473113_T_C
Allele freq

Stratified OR
|
|
G param by E
|
|
|
TT
|
TC
|
CC
|
TC
|
CC
|
|
redmeatqcm_v2=0
|
1
|
0.93 (0.88-0.99)
|
0.89 (0.83-0.96)
|
0.93 (0.88-0.99)
|
0.89 (0.83-0.96)
|
|
p0
|
P= 1
|
P= 0.028
|
P= 0.0019
|
P= 0.028
|
P= 0.0019
|
|
redmeatqcm_v2=1
|
1.12 (1.04-1.21)
|
1.18 (1.11-1.26)
|
1.26 (1.17-1.36)
|
1.05 (1-1.11)
|
1.12 (1.06-1.2)
|
|
p1
|
P= 0.0025
|
P= 5.7e-07
|
P= 8.5e-10
|
P= 0.049
|
P= 0.00025
|
|
E param by G
|
|
redmeatqcm_v2
|
1.12 (1.04-1.21)
|
1.27 (1.19-1.34)
|
1.42 (1.31-1.54)
|
|
|
|
p
|
P= 0.0025
|
P= 5.8e-15
|
P= 4.3e-17
|
|
|
Interaction Plot

Locuszoom

2DF findings
chr8_120042899_G_T
Allele freq

GxE model by sex
sex stratified chr8_120042899_G_T_dose x redmeatqcm_v2
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=29842,Co=39635)
|
Female (Ca=14569,Co=19615)
|
Male (Ca=15273,Co=20020)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr8_120042899_G_T_dose
|
1.392*** (1.268, 1.516)
|
1.486*** (1.309, 1.662)
|
1.285** (1.102, 1.468)
|
|
redmeatqcm_v2
|
1.270*** (1.222, 1.318)
|
1.260*** (1.181, 1.339)
|
1.297*** (1.235, 1.359)
|
|
age_ref_imp
|
1.000 (0.998, 1.002)
|
1.000 (0.998, 1.003)
|
0.999 (0.997, 1.002)
|
|
sex
|
0.975 (0.939, 1.011)
|
|
|
|
energytot_imp
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
1.000* (1.000, 1.000)
|
|
chr8_120042899_G_T_dose:redmeatqcm_v2
|
0.808* (0.641, 0.974)
|
0.751* (0.473, 1.029)
|
0.868 (0.653, 1.084)
|
|
Constant
|
0.828* (0.678, 0.977)
|
0.698** (0.479, 0.918)
|
0.928 (0.721, 1.134)
|
|
|
|
Observations
|
69,477
|
34,184
|
35,293
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
2DF LRtest p = 3.0765e-08
|
|
|
2DF LRtest p = 2.2228e-06
|
|
|
2DF LRtest p = 9.0278e-03
|
GxE model by study design
study_design stratified chr8_120042899_G_T_dose x redmeatqcm_v2
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=29842,Co=39635)
|
Cohort (Ca=12795,Co=24665)
|
Case-Control (Ca=17047,Co=14970)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr8_120042899_G_T_dose
|
1.392*** (1.268, 1.516)
|
1.465*** (1.297, 1.633)
|
1.317** (1.134, 1.501)
|
|
redmeatqcm_v2
|
1.270*** (1.222, 1.318)
|
1.156*** (1.090, 1.222)
|
1.447*** (1.375, 1.519)
|
|
age_ref_imp
|
1.000 (0.998, 1.002)
|
1.002 (0.999, 1.006)
|
0.999 (0.997, 1.001)
|
|
sex
|
0.975 (0.939, 1.011)
|
0.996 (0.940, 1.052)
|
0.944* (0.896, 0.991)
|
|
energytot_imp
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
1.000*** (1.000, 1.000)
|
|
chr8_120042899_G_T_dose:redmeatqcm_v2
|
0.808* (0.641, 0.974)
|
0.809 (0.586, 1.033)
|
0.796 (0.544, 1.047)
|
|
Constant
|
0.828* (0.678, 0.977)
|
4.538*** (4.079, 4.997)
|
0.872 (0.702, 1.042)
|
|
|
|
Observations
|
69,477
|
37,460
|
32,017
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
2DF LRtest p = 3.0765e-08
|
|
|
2DF LRtest p = 1.3670e-06
|
|
|
2DF LRtest p = 7.8400e-03
|
GxE model by tumor site
cancer_site_sum2 stratified chr8_120042899_G_T_dose x redmeatqcm_v2
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=29842,Co=39635)
|
Proximal (Ca=9044,Co=39635)
|
Distal (Ca=10519,Co=39635)
|
Rectal (Ca=8424,Co=39635)
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
chr8_120042899_G_T_dose
|
1.392*** (1.268, 1.516)
|
1.370*** (1.190, 1.550)
|
1.360*** (1.183, 1.536)
|
1.429*** (1.233, 1.626)
|
|
redmeatqcm_v2
|
1.270*** (1.222, 1.318)
|
1.350*** (1.280, 1.420)
|
1.243*** (1.178, 1.309)
|
1.293*** (1.216, 1.369)
|
|
age_ref_imp
|
1.000 (0.998, 1.002)
|
0.995*** (0.993, 0.998)
|
1.018*** (1.016, 1.021)
|
0.985*** (0.983, 0.988)
|
|
sex
|
0.975 (0.939, 1.011)
|
1.006 (0.953, 1.060)
|
0.782*** (0.730, 0.834)
|
1.235*** (1.180, 1.291)
|
|
energytot_imp
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
|
chr8_120042899_G_T_dose:redmeatqcm_v2
|
0.808* (0.641, 0.974)
|
0.868 (0.636, 1.100)
|
0.795 (0.562, 1.027)
|
0.706* (0.422, 0.989)
|
|
Constant
|
0.828* (0.678, 0.977)
|
0.467*** (0.261, 0.673)
|
0.079*** (-0.144, 0.302)
|
0.547*** (0.327, 0.766)
|
|
|
|
Observations
|
69,477
|
48,679
|
50,154
|
48,059
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
2DF LRtest p = 3.0765e-08
|
|
|
2DF LRtest p = 1.4735e-04
|
|
|
2DF LRtest p = 1.5193e-03
|
|
|
2DF LRtest p = 1.5964e-03
|
Stratified OR
|
|
G param by E
|
|
|
GG
|
GT
|
TT
|
GT
|
TT
|
|
redmeatqcm_v2=0
|
1
|
1.4 (1.23-1.59)
|
1.68 (0.55-5.1)
|
1.4 (1.23-1.59)
|
1.68 (0.55-5.1)
|
|
p0
|
P= 1
|
P= 3.3e-07
|
P= 0.36
|
P= 3.3e-07
|
P= 0.36
|
|
redmeatqcm_v2=1
|
1.27 (1.21-1.33)
|
1.43 (1.28-1.6)
|
1.48 (0.74-2.96)
|
1.13 (1.01-1.25)
|
1.16 (0.58-2.33)
|
|
p1
|
P= 2.1e-22
|
P= 2.1e-10
|
P= 0.27
|
P= 0.026
|
P= 0.67
|
|
E param by G
|
|
redmeatqcm_v2
|
1.27 (1.21-1.33)
|
1.03 (0.86-1.22)
|
0.88 (0.26-3.02)
|
|
|
|
p
|
P= 2.1e-22
|
P= 0.77
|
P= 0.84
|
|
|
Interaction Plot

Locuszoom

Func Annot

chr8_122247679_C_G
Allele freq

GxE model by sex
sex stratified chr8_122247679_C_G_dose x redmeatqcm_v2
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=29842,Co=39635)
|
Female (Ca=14569,Co=19615)
|
Male (Ca=15273,Co=20020)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr8_122247679_C_G_dose
|
1.033 (0.994, 1.072)
|
1.037 (0.981, 1.094)
|
1.023 (0.968, 1.078)
|
|
redmeatqcm_v2
|
1.372*** (1.313, 1.432)
|
1.338*** (1.240, 1.437)
|
1.412*** (1.336, 1.488)
|
|
age_ref_imp
|
1.000 (0.998, 1.002)
|
1.000 (0.998, 1.003)
|
0.999 (0.997, 1.002)
|
|
sex
|
0.974 (0.937, 1.010)
|
|
|
|
energytot_imp
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
1.000* (1.000, 1.000)
|
|
chr8_122247679_C_G_dose:redmeatqcm_v2
|
0.876*** (0.823, 0.929)
|
0.892* (0.801, 0.983)
|
0.872*** (0.805, 0.938)
|
|
Constant
|
0.824* (0.672, 0.976)
|
0.696** (0.474, 0.919)
|
0.924 (0.715, 1.134)
|
|
|
|
Observations
|
69,477
|
34,184
|
35,293
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
2DF LRtest p = 1.2062e-08
|
|
|
2DF LRtest p = 2.5094e-02
|
|
|
2DF LRtest p = 1.4500e-07
|
GxE model by study design
study_design stratified chr8_122247679_C_G_dose x redmeatqcm_v2
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=29842,Co=39635)
|
Cohort (Ca=12795,Co=24665)
|
Case-Control (Ca=17047,Co=14970)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr8_122247679_C_G_dose
|
1.033 (0.994, 1.072)
|
1.047 (0.990, 1.103)
|
1.026 (0.972, 1.079)
|
|
redmeatqcm_v2
|
1.372*** (1.313, 1.432)
|
1.240*** (1.159, 1.321)
|
1.585*** (1.497, 1.674)
|
|
age_ref_imp
|
1.000 (0.998, 1.002)
|
1.002 (0.999, 1.006)
|
0.999 (0.997, 1.001)
|
|
sex
|
0.974 (0.937, 1.010)
|
0.995 (0.939, 1.051)
|
0.943* (0.895, 0.990)
|
|
energytot_imp
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
1.000*** (1.000, 1.000)
|
|
chr8_122247679_C_G_dose:redmeatqcm_v2
|
0.876*** (0.823, 0.929)
|
0.886** (0.814, 0.959)
|
0.858*** (0.779, 0.936)
|
|
Constant
|
0.824* (0.672, 0.976)
|
4.541*** (4.080, 5.001)
|
0.871 (0.698, 1.044)
|
|
|
|
Observations
|
69,477
|
37,460
|
32,017
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
2DF LRtest p = 1.2062e-08
|
|
|
2DF LRtest p = 1.3258e-03
|
|
|
2DF LRtest p = 2.4918e-06
|
GxE model by tumor site
cancer_site_sum2 stratified chr8_122247679_C_G_dose x redmeatqcm_v2
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=29842,Co=39635)
|
Proximal (Ca=9044,Co=39635)
|
Distal (Ca=10519,Co=39635)
|
Rectal (Ca=8424,Co=39635)
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
chr8_122247679_C_G_dose
|
1.033 (0.994, 1.072)
|
1.047 (0.990, 1.105)
|
1.038 (0.983, 1.093)
|
1.005 (0.944, 1.066)
|
|
redmeatqcm_v2
|
1.372*** (1.313, 1.432)
|
1.497*** (1.412, 1.582)
|
1.331*** (1.250, 1.412)
|
1.358*** (1.263, 1.452)
|
|
age_ref_imp
|
1.000 (0.998, 1.002)
|
0.995*** (0.993, 0.998)
|
1.018*** (1.016, 1.021)
|
0.985*** (0.983, 0.988)
|
|
sex
|
0.974 (0.937, 1.010)
|
1.005 (0.952, 1.058)
|
0.782*** (0.730, 0.834)
|
1.235*** (1.179, 1.290)
|
|
energytot_imp
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
|
chr8_122247679_C_G_dose:redmeatqcm_v2
|
0.876*** (0.823, 0.929)
|
0.846*** (0.769, 0.923)
|
0.887** (0.814, 0.960)
|
0.907* (0.823, 0.992)
|
|
Constant
|
0.824* (0.672, 0.976)
|
0.461*** (0.252, 0.670)
|
0.079*** (-0.147, 0.305)
|
0.555*** (0.331, 0.778)
|
|
|
|
Observations
|
69,477
|
48,679
|
50,154
|
48,059
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
2DF LRtest p = 1.2062e-08
|
|
|
2DF LRtest p = 1.8136e-06
|
|
|
2DF LRtest p = 8.6551e-04
|
|
|
2DF LRtest p = 2.3498e-03
|
Stratified OR
|
|
G param by E
|
|
|
CC
|
CG
|
GG
|
CG
|
GG
|
|
redmeatqcm_v2=0
|
1
|
1.03 (0.98-1.09)
|
1.07 (0.98-1.16)
|
1.03 (0.98-1.09)
|
1.07 (0.98-1.16)
|
|
p0
|
P= 1
|
P= 0.24
|
P= 0.14
|
P= 0.24
|
P= 0.14
|
|
redmeatqcm_v2=1
|
1.38 (1.29-1.46)
|
1.24 (1.16-1.31)
|
1.14 (1.05-1.24)
|
0.9 (0.86-0.94)
|
0.83 (0.77-0.89)
|
|
p1
|
P= 4.1e-24
|
P= 4.7e-12
|
P= 0.0023
|
P= 6e-06
|
P= 3.8e-07
|
|
E param by G
|
|
redmeatqcm_v2
|
1.38 (1.29-1.46)
|
1.2 (1.12-1.27)
|
1.07 (0.95-1.19)
|
|
|
|
p
|
P= 4.1e-24
|
P= 1.5e-08
|
P= 0.25
|
|
|
Interaction Plot

Locuszoom

Func Annot

chr10_86469912_G_A
Allele freq

GxE model by sex
sex stratified chr10_86469912_G_A_dose x redmeatqcm_v2
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=29842,Co=39635)
|
Female (Ca=14569,Co=19615)
|
Male (Ca=15273,Co=20020)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr10_86469912_G_A_dose
|
1.504*** (1.350, 1.658)
|
1.515*** (1.293, 1.738)
|
1.581*** (1.360, 1.801)
|
|
redmeatqcm_v2
|
1.266*** (1.218, 1.313)
|
1.256*** (1.177, 1.334)
|
1.296*** (1.234, 1.357)
|
|
age_ref_imp
|
1.000 (0.998, 1.002)
|
1.000 (0.998, 1.003)
|
0.999 (0.997, 1.002)
|
|
sex
|
0.973 (0.937, 1.009)
|
|
|
|
energytot_imp
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
1.000* (1.000, 1.000)
|
|
chr10_86469912_G_A_dose:redmeatqcm_v2
|
0.774* (0.556, 0.991)
|
0.653* (0.284, 1.023)
|
0.805 (0.529, 1.081)
|
|
Constant
|
0.828* (0.679, 0.978)
|
0.703** (0.483, 0.922)
|
0.921 (0.714, 1.127)
|
|
|
|
Observations
|
69,477
|
34,184
|
35,293
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
2DF LRtest p = 3.6599e-08
|
|
|
2DF LRtest p = 7.3955e-04
|
|
|
2DF LRtest p = 8.8525e-06
|
GxE model by study design
study_design stratified chr10_86469912_G_A_dose x redmeatqcm_v2
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=29842,Co=39635)
|
Cohort (Ca=12795,Co=24665)
|
Case-Control (Ca=17047,Co=14970)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr10_86469912_G_A_dose
|
1.504*** (1.350, 1.658)
|
1.410** (1.196, 1.624)
|
1.595*** (1.371, 1.819)
|
|
redmeatqcm_v2
|
1.266*** (1.218, 1.313)
|
1.150*** (1.084, 1.215)
|
1.443*** (1.372, 1.514)
|
|
age_ref_imp
|
1.000 (0.998, 1.002)
|
1.003 (0.999, 1.006)
|
0.999 (0.997, 1.001)
|
|
sex
|
0.973 (0.937, 1.009)
|
0.994 (0.938, 1.050)
|
0.943* (0.896, 0.990)
|
|
energytot_imp
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
1.000*** (1.000, 1.000)
|
|
chr10_86469912_G_A_dose:redmeatqcm_v2
|
0.774* (0.556, 0.991)
|
0.858 (0.568, 1.148)
|
0.692* (0.360, 1.024)
|
|
Constant
|
0.828* (0.679, 0.978)
|
4.558*** (4.099, 5.017)
|
0.871 (0.702, 1.041)
|
|
|
|
Observations
|
69,477
|
37,460
|
32,017
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
2DF LRtest p = 3.6599e-08
|
|
|
2DF LRtest p = 5.5830e-04
|
|
|
2DF LRtest p = 6.2346e-05
|
GxE model by tumor site
cancer_site_sum2 stratified chr10_86469912_G_A_dose x redmeatqcm_v2
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=29842,Co=39635)
|
Proximal (Ca=9044,Co=39635)
|
Distal (Ca=10519,Co=39635)
|
Rectal (Ca=8424,Co=39635)
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
chr10_86469912_G_A_dose
|
1.504*** (1.350, 1.658)
|
1.508*** (1.282, 1.733)
|
1.527*** (1.316, 1.738)
|
1.647*** (1.405, 1.888)
|
|
redmeatqcm_v2
|
1.266*** (1.218, 1.313)
|
1.349*** (1.280, 1.418)
|
1.237*** (1.172, 1.302)
|
1.286*** (1.210, 1.362)
|
|
age_ref_imp
|
1.000 (0.998, 1.002)
|
0.995*** (0.993, 0.998)
|
1.018*** (1.016, 1.021)
|
0.985*** (0.983, 0.988)
|
|
sex
|
0.973 (0.937, 1.009)
|
1.005 (0.952, 1.059)
|
0.781*** (0.729, 0.833)
|
1.235*** (1.180, 1.291)
|
|
energytot_imp
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
|
chr10_86469912_G_A_dose:redmeatqcm_v2
|
0.774* (0.556, 0.991)
|
0.774 (0.458, 1.090)
|
0.799 (0.505, 1.093)
|
0.641* (0.281, 1.001)
|
|
Constant
|
0.828* (0.679, 0.978)
|
0.468*** (0.262, 0.674)
|
0.079*** (-0.144, 0.303)
|
0.547*** (0.328, 0.767)
|
|
|
|
Observations
|
69,477
|
48,679
|
50,154
|
48,059
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
2DF LRtest p = 3.6599e-08
|
|
|
2DF LRtest p = 4.4459e-04
|
|
|
2DF LRtest p = 3.4325e-05
|
|
|
2DF LRtest p = 2.0981e-04
|
Stratified OR
|
|
G param by E
|
|
|
GG
|
GA
|
AA
|
GA
|
AA
|
|
redmeatqcm_v2=0
|
1
|
1.54 (1.31-1.8)
|
0.98 (0.25-3.84)
|
1.54 (1.31-1.8)
|
0.98 (0.25-3.84)
|
|
p0
|
P= 1
|
P= 9.4e-08
|
P= 0.97
|
P= 9.4e-08
|
P= 0.97
|
|
redmeatqcm_v2=1
|
1.27 (1.21-1.33)
|
1.47 (1.27-1.7)
|
2.06 (0.49-8.72)
|
1.16 (1.01-1.34)
|
1.63 (0.39-6.88)
|
|
p1
|
P= 3.9e-22
|
P= 1.7e-07
|
P= 0.32
|
P= 0.038
|
P= 0.51
|
|
E param by G
|
|
redmeatqcm_v2
|
1.27 (1.21-1.33)
|
0.95 (0.77-1.19)
|
2.11 (0.24-18.83)
|
|
|
|
p
|
P= 3.9e-22
|
P= 0.68
|
P= 0.5
|
|
|
Interaction Plot

Locuszoom

Func Annot

3DF findings
(same locus as 2DF) – see above
Two-step findings
chr18_46453754_C_T
Allele freq

GxE model by sex
sex stratified chr18_46453754_C_T_dose x redmeatqcm_v2
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=29842,Co=39635)
|
Female (Ca=14569,Co=19615)
|
Male (Ca=15273,Co=20020)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr18_46453754_C_T_dose
|
0.820*** (0.777, 0.863)
|
0.811*** (0.748, 0.874)
|
0.827*** (0.766, 0.889)
|
|
redmeatqcm_v2
|
1.180*** (1.124, 1.237)
|
1.154** (1.060, 1.247)
|
1.217*** (1.145, 1.289)
|
|
age_ref_imp
|
1.000 (0.998, 1.002)
|
1.000 (0.998, 1.003)
|
1.000 (0.997, 1.002)
|
|
sex
|
0.973 (0.937, 1.009)
|
|
|
|
energytot_imp
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
1.000* (1.000, 1.000)
|
|
chr18_46453754_C_T_dose:redmeatqcm_v2
|
1.129*** (1.070, 1.188)
|
1.149** (1.048, 1.249)
|
1.118** (1.044, 1.192)
|
|
Constant
|
0.926 (0.775, 1.077)
|
0.794* (0.572, 1.016)
|
1.022 (0.814, 1.231)
|
|
|
|
Observations
|
69,477
|
34,184
|
35,293
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 4.8149e-05
|
|
|
GxE term LRtest p = 6.7079e-03
|
|
|
GxE term LRtest p = 3.0407e-03
|
GxE model by study design
study_design stratified chr18_46453754_C_T_dose x redmeatqcm_v2
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=29842,Co=39635)
|
Cohort (Ca=12795,Co=24665)
|
Case-Control (Ca=17047,Co=14970)
|
|
|
(1)
|
(2)
|
(3)
|
|
|
|
chr18_46453754_C_T_dose
|
0.820*** (0.777, 0.863)
|
0.834*** (0.772, 0.896)
|
0.807*** (0.746, 0.868)
|
|
redmeatqcm_v2
|
1.180*** (1.124, 1.237)
|
1.082* (1.005, 1.159)
|
1.333*** (1.250, 1.416)
|
|
age_ref_imp
|
1.000 (0.998, 1.002)
|
1.002 (0.999, 1.006)
|
0.999 (0.997, 1.002)
|
|
sex
|
0.973 (0.937, 1.009)
|
0.995 (0.939, 1.052)
|
0.942* (0.894, 0.989)
|
|
energytot_imp
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
1.000*** (1.000, 1.000)
|
|
chr18_46453754_C_T_dose:redmeatqcm_v2
|
1.129*** (1.070, 1.188)
|
1.115** (1.036, 1.194)
|
1.147** (1.059, 1.235)
|
|
Constant
|
0.926 (0.775, 1.077)
|
5.085*** (4.625, 5.546)
|
0.981 (0.809, 1.153)
|
|
|
|
Observations
|
69,477
|
37,460
|
32,017
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 4.8149e-05
|
|
|
GxE term LRtest p = 6.9183e-03
|
|
|
GxE term LRtest p = 2.3280e-03
|
GxE model by tumor site
cancer_site_sum2 stratified chr18_46453754_C_T_dose x redmeatqcm_v2
|
|
|
|
Dependent variable:
|
|
|
|
|
|
outcome
|
|
|
All (Ca=29842,Co=39635)
|
Proximal (Ca=9044,Co=39635)
|
Distal (Ca=10519,Co=39635)
|
Rectal (Ca=8424,Co=39635)
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
chr18_46453754_C_T_dose
|
0.820*** (0.777, 0.863)
|
0.784*** (0.719, 0.848)
|
0.844*** (0.783, 0.906)
|
0.824*** (0.756, 0.892)
|
|
redmeatqcm_v2
|
1.180*** (1.124, 1.237)
|
1.259*** (1.179, 1.340)
|
1.144*** (1.067, 1.221)
|
1.207*** (1.118, 1.296)
|
|
age_ref_imp
|
1.000 (0.998, 1.002)
|
0.995*** (0.993, 0.998)
|
1.018*** (1.016, 1.021)
|
0.985*** (0.983, 0.988)
|
|
sex
|
0.973 (0.937, 1.009)
|
1.004 (0.951, 1.057)
|
0.781*** (0.729, 0.833)
|
1.233*** (1.178, 1.289)
|
|
energytot_imp
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
1.000* (1.000, 1.000)
|
1.000 (1.000, 1.000)
|
|
chr18_46453754_C_T_dose:redmeatqcm_v2
|
1.129*** (1.070, 1.188)
|
1.131** (1.046, 1.216)
|
1.146*** (1.066, 1.226)
|
1.103* (1.009, 1.197)
|
|
Constant
|
0.926 (0.775, 1.077)
|
0.533*** (0.325, 0.741)
|
0.088*** (-0.138, 0.313)
|
0.612*** (0.391, 0.834)
|
|
|
|
Observations
|
69,477
|
48,679
|
50,154
|
48,059
|
|
|
|
Note:
|
p<0.05; p<0.01; p<0.001
|
|
|
(PC and Study estimates omitted from table)
|
|
|
GxE term LRtest p = 4.8149e-05
|
|
|
GxE term LRtest p = 4.5998e-03
|
|
|
GxE term LRtest p = 8.7023e-04
|
|
|
GxE term LRtest p = 4.1705e-02
|
Stratified OR
|
|
G param by E
|
|
|
CC
|
CT
|
TT
|
CT
|
TT
|
|
redmeatqcm_v2=0
|
1
|
0.83 (0.79-0.88)
|
0.65 (0.58-0.73)
|
0.83 (0.79-0.88)
|
0.65 (0.58-0.73)
|
|
p0
|
P= 1
|
P= 2e-10
|
P= 8.1e-14
|
P= 2e-10
|
P= 8.1e-14
|
|
redmeatqcm_v2=1
|
1.17 (1.11-1.24)
|
1.13 (1.06-1.19)
|
0.94 (0.85-1.04)
|
0.96 (0.91-1.01)
|
0.8 (0.73-0.88)
|
|
p1
|
P= 4.2e-08
|
P= 0.0001
|
P= 0.25
|
P= 0.08
|
P= 3.9e-06
|
|
E param by G
|
|
redmeatqcm_v2
|
1.17 (1.11-1.24)
|
1.35 (1.26-1.44)
|
1.46 (1.26-1.68)
|
|
|
|
p
|
P= 4.2e-08
|
P= 9.5e-19
|
P= 5.2e-07
|
|
|
Interaction Plot

Locuszoom

Func Annot

E|G finding (combined case-control sample)
(SNP associated with meat intake)
chr19_49232226_G_A
Allele freq

Locuszoom

Func Annot
